Synthesis of novel cytotoxic tetracyclic acridone derivatives and study of their molecular docking, ADMET, QSAR, bioactivity and protein binding properties

Acridone based synthetic and natural products with inherent anticancer activity advancing the research and generating a large number of structurally diversified compounds. In this sequence we have designed, synthesized a series of tetracyclic acridones with amide framework viz., 3-(alkyloyl/ aryloyl...

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Publicado en:Sci Rep
Autores principales: Veligeti, Rajkumar, Madhu, Rajesh Bagepalli, Anireddy, Jayashree, Pasupuleti, Visweswara Rao, Avula, Vijaya Kumar Reddy, Ethiraj, Krishna S., Uppalanchi, Srinivas, Kasturi, Sivaprasad, Perumal, Yogeeswari, Anantaraju, Hasitha Shilpa, Polkam, Naveen, Guda, Mallilkarjuna Reddy, Vallela, Swetha, Zyryanov, Grigory Vasilievich
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7691360/
https://ncbi.nlm.nih.gov/pubmed/33244007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77590-1
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