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Target-Mediated Brain Tissue Binding for Small Molecule Inhibitors of Heat Shock Protein 90
Drug distribution in the brain is generally associated with an affinity for fatty brain tissues and therefore known to be species- and concentration-independent. We report here the effect of target affinity on brain tissue binding for 10 small molecules designed to inhibit brain heat shock protein 9...
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| Pubblicato in: | Pharmaceutics |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7690585/ https://ncbi.nlm.nih.gov/pubmed/33105895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12111009 |
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