HER2 antibody-drug conjugate controls growth of breast cancer brain metastases in hematogenous xenograft models, with heterogeneous blood–tumor barrier penetration unlinked to a passive marker

BACKGROUND: Brain metastases of HER2+ breast cancer persist as a clinical challenge. Many therapeutics directed at human epidermal growth factor receptor 2 (HER2) are antibodies or antibody-drug conjugates (ADCs), and their permeability through the blood–tumor barrier (BTB) is poorly understood. We...

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Vydáno v:Neuro Oncol
Hlavní autoři: Gril, Brunilde, Wei, Debbie, Zimmer, Alexandra S, Robinson, Christina, Khan, Imran, Difilippantonio, Simone, Overstreet, Michael G, Steeg, Patricia S
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7690367/
https://ncbi.nlm.nih.gov/pubmed/32386414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa118
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