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A Bayesian hierarchical variable selection prior for pathway-based GWAS using summary statistics

While genome-wide association studies (GWASs) have been widely used to uncover associations between diseases and genetic variants, standard SNP-level GWASs often lack the power to identify SNPs that individually have a moderate effect size but jointly contribute to the disease. To overcome this prob...

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Bibliographische Detailangaben
Veröffentlicht in:Stat Med
Hauptverfasser: Yang, Yi, Basu, Saonli, Zhang, Lin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7690328/
https://ncbi.nlm.nih.gov/pubmed/31777110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.8442
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