Relative contributions of family history and a polygenic risk score on COPD and related outcomes: COPDGene and ECLIPSE studies

INTRODUCTION: Family history is a risk factor for chronic obstructive pulmonary disease (COPD). We previously developed a COPD risk score from genome-wide genetic markers (Polygenic Risk Score, PRS). Whether the PRS and family history provide complementary or redundant information for predicting COP...

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Detalles Bibliográficos
Publicado en:BMJ Open Respir Res
Main Authors: Moll, Matthew, Lutz, Sharon M., Ghosh, Auyon J., Sakornsakolpat, Phuwanat, Hersh, Craig P., Beaty, Terri H., Dudbridge, Frank, Tobin, Martin D., Mittleman, Murray A., Silverman, Edwin K., Hobbs, Brian D., Cho, Michael H.
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2020
Assuntos:
Chronic Obstructive Pulmonary Disease
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689586/
https://ncbi.nlm.nih.gov/pubmed/33239407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/bmjresp-2020-000755
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