Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1

Selective neuronal vulnerability in neurodegenerative disease is poorly understood. Using the ATXN1[82Q] model of spinocerebellar ataxia type 1 (SCA1), we explored the hypothesis that regional differences in Purkinje neuron degeneration could provide novel insights into selective vulnerability. ATXN...

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Udgivet i:Hum Mol Genet
Main Authors: Chopra, Ravi, Bushart, David D, Cooper, John P, Yellajoshyula, Dhananjay, Morrison, Logan M, Huang, Haoran, Handler, Hillary P, Man, Luke J, Dansithong, Warunee, Scoles, Daniel R, Pulst, Stefan M, Orr, Harry T, Shakkottai, Vikram G
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
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General Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689299/
https://ncbi.nlm.nih.gov/pubmed/32964235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa212
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