A Novel Synthetic Interfering Peptide Tat-3L4F Attenuates Olanzapine-Induced Weight Gain Through Disrupting Crosstalk Between Serotonin Receptor 2C and Protein Phosphatase and Tensin Homolog in Rats

BACKGROUND: Accompanied with profound efficacy, atypical antipsychotics (AAPs) contribute to metabolic adverse effects with few effective strategies to attenuate. Serotonin 5-HT2C receptor (HTR2C) plays a critical role in hyperphagia and weight gain induced by AAPs, and expression of phosphatase ten...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Neuropsychopharmacol
Hauptverfasser: Wang, Yewei, Wang, Dandan, Chen, Yan, Fang, Xinyu, Yu, Lingfang, Zhang, Chen
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
Schlagworte:
Regular Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689208/
https://ncbi.nlm.nih.gov/pubmed/32710540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyaa001
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