Polygenic Risk Score for Early Prediction of Sepsis Risk in the Polytrauma Screening Cohort

BACKGROUND: Increasing genetic variants associated with sepsis have been identified by candidate-gene and genome-wide association studies, but single variants conferred minimal alterations in risk prediction. Our aim is to evaluate whether a weighted genetic risk score (wGRS) that aggregates informa...

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Vydáno v:Front Genet
Hlavní autoři: Lu, Hongxiang, Wen, Dalin, Sun, Jianhui, Du, Juan, Qiao, Liang, Zhang, Huacai, Zeng, Ling, Zhang, Lianyang, Jiang, Jianxin, Zhang, Anqiang
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Genetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7689156/
https://ncbi.nlm.nih.gov/pubmed/33281864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.545564
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