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D- and Unnatural Amino Acid Substituted Antimicrobial Peptides With Improved Proteolytic Resistance and Their Proteolytic Degradation Characteristics

The transition of antimicrobial peptides (AMPs) from the laboratory to market has been severely hindered by their instability toward proteases in biological systems. In the present study, we synthesized derivatives of the cationic AMP Pep05 (KRLFKKLLKYLRKF) by substituting L-amino acid residues with...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Front Microbiol
Main Authors: Lu, Jianguang, Xu, Hongjiang, Xia, Jianghua, Ma, Jie, Xu, Jun, Li, Yanan, Feng, Jun
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688903/
https://ncbi.nlm.nih.gov/pubmed/33281761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2020.563030
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