Inhibition of PFKFB3 Hampers the Progression of Atherosclerosis and Promotes Plaque Stability

AIMS: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase (PFKFB)3-mediated glycolysis is pivotal in driving macrophage- and endothelial cell activation and thereby inflammation. Once activated, these cells play a crucial role in the progression of atherosclerosis. Here, we analyzed the expression o...

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Detalhes bibliográficos
Publicado no:Front Cell Dev Biol
Main Authors: Poels, Kikkie, Schnitzler, Johan G., Waissi, Farahnaz, Levels, Johannes H. M., Stroes, Erik S. G., Daemen, Mat J. A. P., Lutgens, Esther, Pennekamp, Anne-Marije, De Kleijn, Dominique P. V., Seijkens, Tom T. P., Kroon, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688893/
https://ncbi.nlm.nih.gov/pubmed/33282864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fcell.2020.581641
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