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Extracellular Citrate Is a Trojan Horse for Cancer Cells
The first intermediate in the mitochondrial tricarboxylic acid (TCA) cycle is citrate, which is essential and acts as a metabolic regulator for glycolysis, TCA cycle, gluconeogenesis, and fatty acid synthesis. Within the cytosol, citrate is cleaved by ATP citrate lyase (ACLY) into oxaloacetate (OAA)...
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| Publicado no: | Front Mol Biosci |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7688668/ https://ncbi.nlm.nih.gov/pubmed/33282912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2020.593866 |
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