Detection of KRAS mutations in liquid biopsies from metastatic colorectal cancer patients using droplet digital PCR, Idylla, and next generation sequencing

Circulating tumor DNA (ctDNA) is released from cancer cells and oncogenic mutations in ctDNA can be measured from plasma samples. Droplet digital PCR (ddPCR) is a sensitive and specific method for the detection of mutations in ctDNA. We analyzed serial plasma samples (n = 80) from ten metastatic col...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Holm, Matilda, Andersson, Emma, Osterlund, Emerik, Ovissi, Ali, Soveri, Leena-Maija, Anttonen, Anna-Kaisa, Kytölä, Soili, Aittomäki, Kristiina, Osterlund, Pia, Ristimäki, Ari
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688175/
https://ncbi.nlm.nih.gov/pubmed/33237900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239819
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