Detection of KRAS mutations in liquid biopsies from metastatic colorectal cancer patients using droplet digital PCR, Idylla, and next generation sequencing

Circulating tumor DNA (ctDNA) is released from cancer cells and oncogenic mutations in ctDNA can be measured from plasma samples. Droplet digital PCR (ddPCR) is a sensitive and specific method for the detection of mutations in ctDNA. We analyzed serial plasma samples (n = 80) from ten metastatic col...

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Udgivet i:PLoS One
Main Authors: Holm, Matilda, Andersson, Emma, Osterlund, Emerik, Ovissi, Ali, Soveri, Leena-Maija, Anttonen, Anna-Kaisa, Kytölä, Soili, Aittomäki, Kristiina, Osterlund, Pia, Ristimäki, Ari
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7688175/
https://ncbi.nlm.nih.gov/pubmed/33237900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239819
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