Quantitative in Vitro to in Vivo Extrapolation (QIVIVE) for Predicting Reduced Anogenital Distance Produced by Anti-Androgenic Pesticides in a Rodent Model for Male Reproductive Disorders

BACKGROUND: Many pesticides can antagonize the androgen receptor (AR) or inhibit androgen synthesis in vitro but their potential to cause reproductive toxicity related to disruption of androgen action during fetal life is difficult to predict. Currently no approaches for using in vitro data to antic...

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Bibliografski detalji
Izdano u:Environ Health Perspect
Glavni autori: Scholze, Martin, Taxvig, Camilla, Kortenkamp, Andreas, Boberg, Julie, Christiansen, Sofie, Svingen, Terje, Lauschke, Karin, Frandsen, Henrik, Ermler, Sibylle, Hermann, Susan Strange, Pedersen, Mikael, Lykkeberg, Anne Kruse, Axelstad, Marta, Vinggaard, Anne Marie
Format: Artigo
Jezik:Inglês
Izdano: Environmental Health Perspectives 2020
Teme:
Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687371/
https://ncbi.nlm.nih.gov/pubmed/33236927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/EHP6774
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