Empagliflozin reduces the senescence of cardiac stromal cells and improves cardiac function in a murine model of diabetes

The sodium‐glucose cotransporter 2 (SGLT2) inhibitor empagliflozin reduces heart failure in diabetes, but underlying mechanisms remain elusive. We hypothesized that empagliflozin could counteract the senescence of cardiac stromal cells (CSC), the action of which limits cardiac damage and cardiac fib...

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Bibliografiske detaljer
Udgivet i:J Cell Mol Med
Main Authors: Madonna, Rosalinda, Doria, Vanessa, Minnucci, Ilaria, Pucci, Angela, Pierdomenico, Donato Sante, De Caterina, Raffaele
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7687009/
https://ncbi.nlm.nih.gov/pubmed/32940423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.15699
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