Association of Hemochromatosis HFE p.C282Y Homozygosity With Hepatic Malignancy

IMPORTANCE: Hereditary hemochromatosis is predominantly caused by the HFE p.C282Y homozygous pathogenic variant. Liver carcinoma and mortality risks are increased in individuals with clinically diagnosed hereditary hemochromatosis, but risks are unclear in mostly undiagnosed p.C282Y homozygotes iden...

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Bibliographic Details
Published in:JAMA
Main Authors: Atkins, Janice L., Pilling, Luke C., Masoli, Jane A. H., Kuo, Chia-Ling, Shearman, Jeremy D., Adams, Paul C., Melzer, David
Format: Artigo
Language:Inglês
Published: American Medical Association 2020
Subjects:
Original Investigation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686863/
https://ncbi.nlm.nih.gov/pubmed/33231665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2020.21566
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