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Validation of Free Energy Methods in AMBER

Herein we provide high precision validation tests of the latest GPU-accelerated free energy code in AMBER. We demonstrate that consistent free energy results are obtained in both the gas phase and in solution. We first show, in the context of thermodynamic integration (TI), that results are invarian...

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Publicat a:J Chem Inf Model
Autors principals: Tsai, Hsu-Chun, Tao, Yujun, Lee, Tai-Sung, Merz, Kenneth M., York, Darrin M.
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686255/
https://ncbi.nlm.nih.gov/pubmed/32551593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.0c00285
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