E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements

Loss of E-cadherin expression due to mutation of the CDH1 gene is a characteristic feature of invasive lobular breast cancer (ILBC). Beta-catenin, which binds to the cytoplasmic domain of E-cadherin, is simultaneously downregulated, reflecting disassembly of adherens junctions (AJs) and loss of cell...

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Udgivet i:Mod Pathol
Main Authors: Christgen, Matthias, Bartels, Stephan, van Luttikhuizen, Jana L., Bublitz, Janin, Rieger, Luisa U., Christgen, Henriette, Stark, Helge, Sander, Bjoern, Lehmann, Ulrich, Steinemann, Doris, Derksen, Patrick W. B., Kreipe, Hans
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group US 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7685979/
https://ncbi.nlm.nih.gov/pubmed/32572153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41379-020-0591-3
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