Genetic and pharmacological relationship between P-glycoprotein and increased cardiovascular risk associated with clarithromycin prescription: An epidemiological and genomic population-based cohort study in Scotland, UK

BACKGROUND: There are conflicting reports regarding the association of the macrolide antibiotic clarithromycin with cardiovascular (CV) events. A possible explanation may be that this risk is partly mediated through drug–drug interactions and only evident in at-risk populations. To the best of our k...

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Опубликовано в: :PLoS Med
Главные авторы: Mordi, Ify R., Chan, Benjamin K., Yanez, N. David, Palmer, Colin N. A., Lang, Chim C., Chalmers, James D.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2020
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7682888/
https://ncbi.nlm.nih.gov/pubmed/33226983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1003372
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