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Pif1, RPA, and FEN1 modulate the ability of DNA polymerase δ to overcome protein barriers during DNA synthesis

Successful DNA replication requires carefully regulated mechanisms to overcome numerous obstacles that naturally occur throughout chromosomal DNA. Scattered across the genome are tightly bound proteins, such as transcription factors and nucleosomes, that are necessary for cell function, but that als...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Sparks, Melanie A., Burgers, Peter M., Galletto, Roberto
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2020
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681027/
https://ncbi.nlm.nih.gov/pubmed/32913126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.015699
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