Integrin α3β1 on tumor keratinocytes is essential to maintain tumor growth and promotes a tumor-supportive keratinocyte secretome.

Development of integrin-targeted cancer therapies is hindered by incomplete understanding of integrin function in tumor cells and the tumor microenvironment. Previous studies showed that mice with epidermis-specific deletion of the α3 integrin subunit fail to form skin tumors during two-step chemica...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Invest Dermatol
Prif Awduron: Longmate, Whitney M., Varney, Scott, Power, Derek, Pandulal Miskin, Rakshitha, Anderson, Karl E., DeFreest, Lori, Van De Water, Livingston, DiPersio, C. Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7680721/
https://ncbi.nlm.nih.gov/pubmed/32454065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2020.05.080
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