CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML

Understanding the mechanism of small molecules is a critical challenge in chemical biology and drug discovery. Medicinal chemistry is essential for elucidating drug mechanism, enabling variation of small molecule structure to gain structure–activity relationships (SARs). However, the development of...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Vinyard, Michael E., Su, Cindy, Siegenfeld, Allison P., Waterbury, Amanda L., Freedy, Allyson M., Gosavi, Pallavi M., Park, Yongho, Kwan, Eugene E., Senzer, Benjamin D., Doench, John G., Bauer, Daniel E., Pinello, Luca, Liau, Brian B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7679026/
https://ncbi.nlm.nih.gov/pubmed/30992567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0263-0
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