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Age-related epigenetic drift deregulates SIRT6 expression and affects its downstream genes in human peripheral blood mononuclear cells

Sirtuin 6 (SIRT6) exerts a protective effect on health and extends the lives of model organisms. We, therefore, aimed to clarify whether age-related epigenetic drift is responsible for differences in SIRT6 expression in peripheral blood mononuclear cells (PBMCs) of healthy young (n = 55, mean age 27...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Owczarz, Magdalena, Połosak, Jacek, Domaszewska-Szostek, Anna, Kołodziej, Paulina, Kuryłowicz, Alina, Puzianowska-Kuźnicka, Monika
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7678931/
https://ncbi.nlm.nih.gov/pubmed/32573339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2020.1780081
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