LTBK-01. INO-5401 AND INO-9012 DELIVERED INTRAMUSCULARLY (IM) WITH ELECTROPORATION (EP) IN COMBINATION WITH CEMIPLIMAB (REGN2810) IN NEWLY DIAGNOSED GLIOBLASTOMA

BACKGROUND: Novel T cell-enabling therapies, in combination with checkpoint inhibition, may improve OS in GBM. INO-5401 (synthetic DNA plasmids encoding hTERT, WT-1, PSMA) plus INO-9012 (synthetic DNA plasmid encoding IL-12), and the PD-1 immune checkpoint inhibitor cemiplimab, is given to patients...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Reardon, David A, Brem, Steven, Desai, Arati Suvas, Bagley, Stephen Joseph, Kurz, Sylvia Christine, De La Fuente, Macarena Ines, Nagpal, Seema, Welch, Mary Roberta, Hormigo, Adilia, Forsyth, Peter, Mandell, Jacob, Khagi, Simon, Aiken, Robert, Walbert, Tobias, Lieberman, Frank, Portnow, Jana, Batiste, James, Carroll, Nicholas, Sylvester, Albert, Campbell, Patricia, Lowy, Israel, Dolgoter, Alex, Boyer, Jean, Kraynyak, Kimberly, Morrow, Matthew P, McMullan, Trevor, Weiner, David B, Skolnik, Jeffrey
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Late Breaking
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7678727/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.988
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