LTBK-01. INO-5401 AND INO-9012 DELIVERED INTRAMUSCULARLY (IM) WITH ELECTROPORATION (EP) IN COMBINATION WITH CEMIPLIMAB (REGN2810) IN NEWLY DIAGNOSED GLIOBLASTOMA

BACKGROUND: Novel T cell-enabling therapies, in combination with checkpoint inhibition, may improve OS in GBM. INO-5401 (synthetic DNA plasmids encoding hTERT, WT-1, PSMA) plus INO-9012 (synthetic DNA plasmid encoding IL-12), and the PD-1 immune checkpoint inhibitor cemiplimab, is given to patients...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Reardon, David A, Brem, Steven, Desai, Arati Suvas, Bagley, Stephen Joseph, Kurz, Sylvia Christine, De La Fuente, Macarena Ines, Nagpal, Seema, Welch, Mary Roberta, Hormigo, Adilia, Forsyth, Peter, Mandell, Jacob, Khagi, Simon, Aiken, Robert, Walbert, Tobias, Lieberman, Frank, Portnow, Jana, Batiste, James, Carroll, Nicholas, Sylvester, Albert, Campbell, Patricia, Lowy, Israel, Dolgoter, Alex, Boyer, Jean, Kraynyak, Kimberly, Morrow, Matthew P, McMullan, Trevor, Weiner, David B, Skolnik, Jeffrey
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Late Breaking
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7678727/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.988
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