High-throughput screening identifies histone deacetylase inhibitors that modulate GTF2I expression in 7q11.23 microduplication autism spectrum disorder patient-derived cortical neurons

BACKGROUND: Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental condition affecting almost 1% of children, and represents a major unmet medical need with no effective drug treatment available. Duplication at 7q11.23 (7Dup), encompassing 26–28 genes, is one of the best characteriz...

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Detalhes bibliográficos
Publicado no:Mol Autism
Main Authors: Cavallo, Francesca, Troglio, Flavia, Fagà, Giovanni, Fancelli, Daniele, Shyti, Reinald, Trattaro, Sebastiano, Zanella, Matteo, D’Agostino, Giuseppe, Hughes, James M., Cera, Maria Rosaria, Pasi, Maurizio, Gabriele, Michele, Lazzarin, Maddalena, Mihailovich, Marija, Kooy, Frank, Rosa, Alessandro, Mercurio, Ciro, Varasi, Mario, Testa, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677843/
https://ncbi.nlm.nih.gov/pubmed/33208191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-020-00387-6
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