Role of γ-H2AX as a biomarker for detection of bladder carcinogens in F344 rats

Phosphorylation of histone H2AX at serine 139 (γ-H2AX) is known to be induced by direct DNA damage or cellular metabolic imbalances and malfunctions. Previous studies have reported that γ-H2AX is a useful biomarker for early detection of genotoxic bladder carcinogens in rats. The purpose of the pres...

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Publicado en:J Toxicol Pathol
Autores principales: Suzuki, Shugo, Gi, Min, Toyoda, Takeshi, Kato, Hiroyuki, Naiki-Ito, Aya, Kakehashi, Anna, Ogawa, Kumiko, Takahashi, Satoru, Wanibuchi, Hideki
Formato: Artigo
Lenguaje:Inglês
Publicado: Japanese Society of Toxicologic Pathology 2020
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677623/
https://ncbi.nlm.nih.gov/pubmed/33239845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1293/tox.2020-0038
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