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Constitutively active HCN channels constrain detrusor excitability and modulate evoked contractions of human bladder

Objective: Expression of Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is reported in bladder, but the functional role remains unsettled. Here, we immunolocalized the HCN1 and HCN4 subtype in human bladder and investigated their functional significance. Methods: Bladder procured...

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Detalles Bibliográficos
Publicado en:Am J Clin Exp Urol
Main Authors: Kashyap, Mahendra, Singh, Nishant, Yoshimura, Naoki, Chermansky, Christopher, Tyagi, Pradeep
Formato: Artigo
Idioma:Inglês
Publicado: e-Century Publishing Corporation 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677517/
https://ncbi.nlm.nih.gov/pubmed/33235894
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