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Stochastic Gain and Loss of Novel Transcribed Open Reading Frames in the Human Lineage

In addition to known genes, much of the human genome is transcribed into RNA. Chance formation of novel open reading frames (ORFs) can lead to the translation of myriad new proteins. Some of these ORFs may yield advantageous adaptive de novo proteins. However, widespread translation of noncoding DNA...

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Pubblicato in:Genome Biol Evol
Autori principali: Dowling, Daniel, Schmitz, Jonathan F, Bornberg-Bauer, Erich
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674706/
https://ncbi.nlm.nih.gov/pubmed/33210146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gbe/evaa194
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