Spen modulates lipid droplet content in adult Drosophila glial cells and protects against paraquat toxicity

Glial cells are early sensors of neuronal injury and can store lipids in lipid droplets under oxidative stress conditions. Here, we investigated the functions of the RNA-binding protein, SPEN/SHARP, in the context of Parkinson’s disease (PD). Using a data-mining approach, we found that SPEN/SHARP is...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Girard, Victor, Goubard, Valérie, Querenet, Matthieu, Seugnet, Laurent, Pays, Laurent, Nataf, Serge, Dufourd, Eloïse, Cluet, David, Mollereau, Bertrand, Davoust, Nathalie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674452/
https://ncbi.nlm.nih.gov/pubmed/33208773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76891-9
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