Chemical Profiling of A-to-I RNA Editing Using a Click-Compatible Phenylacrylamide

Straightforward methods for detecting adenosine-to-inosine (A-to-I) RNA editing are key to better understanding its regulation, function, and connection with disease. We address this need by developing a novel reagent, N-(4-ethynylphenyl)acrylamide (EPhAA), and illustrating its ability to selectivel...

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Bibliographic Details
Published in:Chemistry
Main Authors: Knutson, Steve D., Korn, Megan M., Johnson, Ryan P, Monteleone, Leanna R., Dailey, Deanna M., Swenson, Colin S., Beal, Peter A., Heemstra, Jennifer M.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674219/
https://ncbi.nlm.nih.gov/pubmed/32428320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.202001667
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