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Imipenem/Cilastatin/Relebactam Alone and in Combination against Pseudomonas aeruginosa in the In Vitro Pharmacodynamic Model

Combination therapy may enhance imipenem/cilastatin/relebactam’s (I/R) activity against Pseudomonas aeruginosa and suppress resistance development. Human-simulated unbound plasma concentrations of I/R at 1.25 g every 6 h (h), colistin at 360 mg daily, and amikacin at 25 mg/kg daily were reproduced a...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Chen, Iris H., Nicolau, David P., Kuti, Joseph L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7674065/
https://ncbi.nlm.nih.gov/pubmed/33139283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01764-20
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