TLR2/6 signaling promotes the expansion of premalignant hematopoietic stem and progenitor cells in the NUP98-HOXD13 mouse model of MDS

Toll-like receptor 2 (TLR2) expression is increased on hematopoietic stem and progenitor cells (HSPCs) of patients with myelodysplastic syndromes (MDS), and enhanced TLR2 signaling is thought to contribute to MDS pathogenesis. Notably, TLR2 heterodimerizes with TLR1 or TLR6, and while high TLR2 is a...

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Udgivet i:Exp Hematol
Main Authors: Monlish, Darlene A., Greenberg, Zev J., Bhatt, Sima T., Leonard, Kathryn M., Romine, Molly P., Dong, Qian, Bendesky, Lauren, Duncavage, Eric J., Magee, Jeffrey A., Schuettpelz, Laura G.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7673652/
https://ncbi.nlm.nih.gov/pubmed/32652111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2020.07.001
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