Serial Systemic Injections of Endotoxin (LPS) Elicit Neuroprotective Spinal Cord Microglia through IL-1-Dependent Cross Talk with Endothelial Cells

Microglia are dynamic immunosurveillance cells in the CNS. Whether microglia are protective or pathologic is context dependent; the outcome varies as a function of time relative to the stimulus, activation state of neighboring cells in the microenvironment or within progression of a particular disea...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Freria, Camila M., Brennan, Faith H., Sweet, David R., Guan, Zhen, Hall, Jodie C., Kigerl, Kristina A., Nemeth, Daniel P., Liu, Xiaoyu, Lacroix, Steve, Quan, Ning, Popovich, Phillip G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2020
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7672996/
https://ncbi.nlm.nih.gov/pubmed/33051350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0131-20.2020
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