STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror Diseases

Store-operated Ca(2+) entry (SOCE) is a ubiquitous and essential mechanism regulating Ca(2+) homeostasis in all tissues, and controls a wide range of cellular functions including keratinocyte differentiation, osteoblastogenesis and osteoclastogenesis, T cell proliferation, platelet activation, and m...

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Udgivet i:Front Physiol
Main Authors: Silva-Rojas, Roberto, Laporte, Jocelyn, Böhm, Johann
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Physiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7672041/
https://ncbi.nlm.nih.gov/pubmed/33250786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2020.604941
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