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DGAT1 protects tumor from lipotoxicity, emerging as a promising metabolic target for cancer therapy
We recently demonstrated that glioblastoma, the most lethal brain cancer, upregulates diacylglycerol O-acyltransferase 1 (DGAT1) to store excess fatty acids into triglycerides to prevent lipotoxicity and promote tumor growth. Targeting DGAT1 resulted in marked tumor cell death by triggering extensiv...
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| Pubblicato in: | Mol Cell Oncol |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Taylor & Francis
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7671038/ https://ncbi.nlm.nih.gov/pubmed/33235909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2020.1805257 |
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