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DRUG MIMICRY: PROMISCUOUS RECEPTORS PXR and AhR AND MICROBIAL METABOLITE INTERACTIONS IN THE INTESTINE
Significant attrition limits drug discovery. The available chemical entities present with drug-like features contribute to this limitation. Using specific examples of promiscuous receptor-ligand interactions, we make a case for expanding the chemical space for drug-like molecules. These ligand-recep...
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| Publicado en: | Trends Pharmacol Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7669654/ https://ncbi.nlm.nih.gov/pubmed/33097284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2020.09.013 |
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