Prevalence of CYP2C8*2 and *3 among Eritreans and its Potential Impact on Artesunate/Amodiaquine Treatment

BACKGROUND: In Eritrea, artesunate–amodiaquine is the first-line treatment against uncomplicated malaria. Amodiaquine, which is mainly bio-transformed by CYP2C8, is known to be associated with adverse events of different severity. Extrapyramidal events are among the less common but have been reporte...

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Опубликовано в: :Pharmgenomics Pers Med
Главные авторы: Habtemikael, Lidia, Russom, Mulugeta, Bahta, Iyassu, Mihreteab, Selam, Berhane, Araia, Mårtensson, Andreas, Gil, Jose Pedro
Формат: Artigo
Язык:Inglês
Опубликовано: Dove 2020
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Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669516/
https://ncbi.nlm.nih.gov/pubmed/33209048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S276215
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