Low-Frequency versus High-Frequency Ultrasound-Mediated Transdermal Delivery of Agomelatine-Loaded Invasomes: Development, Optimization and in-vivo Pharmacokinetic Assessment

AIM: Agomelatine (AGM) is the first melatonergic antidepressant. It suffers from low oral bioavailability (<5%) due to extensive hepatic metabolism. The current work aimed to develop an alternative AGM-loaded invasomes to enhance transdermal drug bioavailability. METHODOLOGY: AGM-loaded invasomes...

Full description

Saved in:
Bibliographic Details
Published in:Int J Nanomedicine
Main Authors: Tawfik, Mai Ahmed, Tadros, Mina Ibrahim, Mohamed, Magdy Ibrahim, Nageeb El-Helaly, Sara
Format: Artigo
Language:Inglês
Published: Dove 2020
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7669507/
https://ncbi.nlm.nih.gov/pubmed/33209023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S283911
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items