Unification of the M/ORF3-related proteins points to a diversified role for ion conductance in pathogenesis of coronaviruses and other nidoviruses

The new coronavirus, SARS-CoV-2, responsible for the COVID-19 pandemic has emphasized the need for a better understanding of the evolution of virus-host conflicts. ORF3a in both SARS-CoV-1 and SARS-CoV-2 are ion channels (viroporins) and involved in virion assembly and membrane budding. Using sensit...

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Vydáno v:bioRxiv
Hlavní autoři: Tan, Yongjun, Schneider, Theresa, Shukla, Prakash K., Chandrasekharan, Mahesh B., Aravind, L, Zhang, Dapeng
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668736/
https://ncbi.nlm.nih.gov/pubmed/33200132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.11.10.377366
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