Phosphatidylinositol-4-kinase IIα licenses phagosomes for TLR4 signaling and MHC-II presentation in dendritic cells

Toll-like receptor (TLR) recruitment to phagosomes in dendritic cells (DCs) and downstream TLR signaling are essential to initiate antimicrobial immune responses. However, the mechanisms underlying TLR localization to phagosomes are poorly characterized. We show herein that phosphatidylinositol-4-ki...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: López-Haber, Cynthia, Levin-Konigsberg, Roni, Zhu, Yueyao, Bi-Karchin, Jing, Balla, Tamas, Grinstein, Sergio, Marks, Michael S., Mantegazza, Adriana R.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668187/
https://ncbi.nlm.nih.gov/pubmed/33109721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001948117
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