KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression

Aberrant programmed cell death protein 1 (PD-1) expression on the surface of T cells is known to inhibit T cell effector activity and to play a pivotal role in tumor immune escape; thus, maintaining an appropriate level of PD-1 expression is of great significance. We identified KLHL22, an adaptor of...

Full description

Saved in:
Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Zhou, Xiao Albert, Zhou, Jiadong, Zhao, Long, Yu, Guihui, Zhan, Jun, Shi, Chanyi, Yuan, Ruoshi, Wang, Yan, Chen, Changfeng, Zhang, Wenjia, Xu, Donghao, Ye, Yingjiang, Wang, Weibin, Shen, Zhanlong, Wang, Wei, Wang, Jiadong
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2020
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7668036/
https://ncbi.nlm.nih.gov/pubmed/33109719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2004570117
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items