The Interplay Between Beta-Amyloid 1–42 (Aβ(1–42))-Induced Hippocampal Inflammatory Response, p-tau, Vascular Pathology, and Their Synergistic Contributions to Neuronal Death and Behavioral Deficits

Alzheimer’s disease (AD), the most common chronic neurodegenerative disorder, has complex neuropathology. The principal neuropathological hallmarks of the disease are the deposition of extracellular β-amyloid (Aβ) plaques and neurofibrillary tangles (NFTs) comprised of hyperphosphorylated tau (p-tau...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Calvo-Flores Guzmán, Beatriz, Elizabeth Chaffey, Tessa, Hansika Palpagama, Thulani, Waters, Sarah, Boix, Jordi, Tate, Warren Perry, Peppercorn, Katie, Dragunow, Michael, Waldvogel, Henry John, Faull, Richard Lewis Maxwell, Kwakowsky, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667153/
https://ncbi.nlm.nih.gov/pubmed/33224025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.552073
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