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Single-Arm Trials with External Comparators and Confounder Misclassification: How Adjustment Can Fail
BACKGROUND: “Single-arm trials” with external comparators that contrast outcomes in those on experimental therapy to real-world patients have been used to evaluate efficacy and safety of experimental drugs in rare and severe diseases. Regulatory agencies are considering expanding the role these stud...
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| Publicado no: | Med Care |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7665993/ https://ncbi.nlm.nih.gov/pubmed/32925456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MLR.0000000000001400 |
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