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Design and Synthesis of Various 5′-Deoxy-5′-(4-Substituted-1,2,3-Triazol-1-yl)-Uridine Analogues as Inhibitors of Mycobacterium tuberculosis Mur Ligases

The synthesis of hitherto unknown 5′-deoxy-5′-(4-substituted-1,2,3-triazol-1-yl)-uridine and its evaluation, through an one-pot screening assay, against MurA-F enzymes involved in Mycobacterium tuberculosis (Mtb), are described. Starting from UDP-N-acetylmuramic acid (UDP-MurNAc), the natural substr...

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Detaylı Bibliyografya
Yayımlandı:Molecules
Asıl Yazarlar: Hervin, Vincent, Arora, Ritu, Rani, Jyoti, Ramchandran, Srinivasan, Bajpai, Urmi, Agrofoglio, Luigi A., Roy, Vincent
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2020
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7663697/
https://ncbi.nlm.nih.gov/pubmed/33114668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25214953
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