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Prolonged Immobilization Exacerbates the Loss of Muscle Mass and Function Induced by Cancer-Associated Cachexia through Enhanced Proteolysis in Mice

We hypothesized that in mice with lung cancer (LC)-induced cachexia, periods of immobilization of the hindlimb (7 and 15 days) may further aggravate the process of muscle mass loss and function. Mice were divided into seven groups (n = 10/group): (1) non-immobilized control mice, (2) 7-day unloaded...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Mañas-García, Laura, Penedo-Vázquez, Antonio, López-Postigo, Adrián, Deschrevel, Jorieke, Durán, Xavier, Barreiro, Esther
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7663403/
https://ncbi.nlm.nih.gov/pubmed/33142912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21218167
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