Accumulation of integrase strand transfer inhibitor resistance mutations confers high-level resistance to dolutegravir in non-B subtype HIV-1 strains from patients failing raltegravir in Uganda

BACKGROUND: Increasing first-line treatment failures in low- and middle-income countries (LMICs) have led to increased use of integrase strand transfer inhibitors (INSTIs) such as dolutegravir. However, HIV-1 susceptibility to INSTIs in LMICs, especially with previous raltegravir exposure, is poorly...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Ndashimye, Emmanuel, Avino, Mariano, Olabode, Abayomi S, Poon, Art F Y, Gibson, Richard M, Li, Yue, Meadows, Adam, Tan, Christine, Reyes, Paul S, Kityo, Cissy M, Kyeyune, Fred, Nankya, Immaculate, Quiñones-Mateu, Miguel E, Arts, Eric J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7662175/
https://ncbi.nlm.nih.gov/pubmed/32853364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa355
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