Genomic Profiling Comparison of Germline BRCA and Non-BRCA Carriers Reveals CCNE1 Amplification as a Risk Factor for Non-BRCA Carriers in Patients With Triple-Negative Breast Cancer

Background: Differences in genomic profiling and immunity-associated parameters between germline BRCA and non-BRCA carriers in TNBC with high tumor burden remain unexplored. This study aimed to compare the differences and explore potential prognostic predictors and therapeutic targets. Methods: The...

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Publicat a:Front Oncol
Autors principals: Huang, Xin, Shao, Di, Wu, Huanwen, Zhu, Changbin, Guo, Dan, Zhou, Yidong, Chen, Chang, Lin, Yan, Lu, Tao, Zhao, Bin, Wang, Changjun, Sun, Qiang
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Oncology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7662137/
https://ncbi.nlm.nih.gov/pubmed/33194720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.583314
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