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Characterization of Affitin proteolytic digestion in biorelevant media and improvement of their stabilities via protein engineering

Affitins are a novel class of small 7 kDa artificial proteins which can be used as antibody substitutes in therapeutic, diagnostic and biotechnological applications. One challenge for this type of protein agent is their behaviour in the context of oral administration. The digestive system is central...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Loussouarn, Aurélie, Béhar, Ghislaine, Pecorari, Frédéric, Croyal, Mikael, Renodon-Cornière, Axelle
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7661517/
https://ncbi.nlm.nih.gov/pubmed/33184451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-76855-z
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