Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking

Carnitine palmitoyltransferase 1C (CPT1C) is a sensor of malonyl-CoA and is located in the ER of neurons. AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain and play a key role in synaptic plasticity. In the present study, we demonstrate across different metabolic stress...

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Pubblicato in:J Cell Biol
Autori principali: Casas, Maria, Fadó, Rut, Domínguez, José Luis, Roig, Aina, Kaku, Moena, Chohnan, Shigeru, Solé, Montse, Unzeta, Mercedes, Miñano-Molina, Alfredo Jesús, Rodríguez-Álvarez, José, Dickson, Eamonn James, Casals, Núria
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659714/
https://ncbi.nlm.nih.gov/pubmed/32931550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201912045
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