Notch1 activation promotes renal cell carcinoma growth via PI3K/Akt signaling

Both the Notch1 and PI3K/Akt pathways are aberrantly activated in clear cell renal cell carcinoma (CCRCC) and involved in the tumorigenesis. The aim of this study was to test our hypothesis that elevated Notch1 signaling activity exerts its growth‐promoting effects via the PI3K/Akt pathway in CCRCC....

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Xu, Le, Zhu, Yu, Xu, Jiejie, Wu, Kerong, Li, Jinfeng, Xu, Wenping, Liu, Haiou, Wang, Shanshan, Yin, Hankun, Chen, Lin, Wang, Guomin, Lin, Zongming
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2012
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7659298/
https://ncbi.nlm.nih.gov/pubmed/22463491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2012.02291.x
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