Combination of magnesium ions and vitamin C alleviates synovitis and osteophyte formation in osteoarthritis of mice

INTRODUCTION: We previously demonstrated that magnesium ions (Mg(2+)) was a novel therapeutic alternative for osteoarthritis (OA) through promoting the hypoxia inducible factor-1α (HIF-1α)-mediated cartilage matrix synthesis. However, oxidative stress can inhibit the expression of HIF-1α, amplify th...

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Опубликовано в: :Bioact Mater
Главные авторы: Yao, Hao, Xu, Jiankun, Wang, Jiali, Zhang, Yifeng, Zheng, Nianye, Yue, Jiang, Mi, Jie, Zheng, Lizhen, Dai, Bingyang, Huang, Wenhan, Yung, Shuhang, Hu, Peijie, Ruan, Yechun, Xue, Qingyun, Ho, Kiwai, Qin, Ling
Формат: Artigo
Язык:Inglês
Опубликовано: KeAi Publishing 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7658330/
https://ncbi.nlm.nih.gov/pubmed/33210027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioactmat.2020.10.016
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